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KMID : 0359720150330010044
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Journal of the Korean Neurological Association
2015 Volume.33 No. 1 p.44 ~ p.47
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Seizure Induction by Artemisia Annua in an Epilepsy Patient Taking Levetiracetam
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Nam Won-Sik
Kwon Oh-Young
Kim Do-Hyung
Kim Min-Jung
Kang Hye-Hoon
Jeong Da-Hye
Jeong Hee-Jeong
Son Seung-Nam
Kim Soo-Kyoung
Kang Hee-Young
Park Ki-Jong
Choi Nack-Cheon
Lim Byeong-Hoon
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Abstract
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Artemisia annua is a wormwood. Because it may induce Cytochrome P450 2C19 enzyme, Artemisia annua may have an influence on antiepileptic drugs which are substrates for the enzyme. This influence may negatively affect seizure control of epilepsy patient. We present a patient whose seizures were induced by Artemisia annua, despite he was taking levetiracetam which is not a substrate for the hepatic enzyme. Therefore there would be another mechanism of seizure induction of Artemisia annua besides hepatic metabolism.
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KEYWORD
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Artemisia annua, Seizure, Anticonvulnts
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